Stone - our trip included Venice, Florence, Cortona (a 4th century BC Etruscan city), Rome, a tour of Pompeii, and ended up in Sorrento, with a private boat tour of Capri.
I thought Cortona and Sorrento were the best, but I cannot knock the museums and sites elsewhere. We stayed at the Villa de Piazzano outside of Cortona. It's where they had the book release party for "Under the Tuscan Sun". Excellent food and wine all over.
My wife came back with all kinds of jewelry. My only souvenirs were an oil painting of Tuscany and 10 extra pounds around my middle.