It is worth remembering that our plants (and us) live in a contaminated world.they are surrounded by a whole range of fungi and bacteria and normally do not show any effect from them. The spots, rot and other ailments occure when there is a cultural problem, imbalance or a biting insect which breaches the plants normal resistance to illness. So to correct this we need to correct the cultural problem, correct the imbalance or remove the biting insect. Most often the first indication we have of a pest (other than mountains of wooly mealy bug, or textured surfaces of scale) are the results of infection of the insect bites. In this case we need to treat not only the insect pest, but the pathogen which has gained access to the plant tissue. I point this out, because all to often the discussion is centered around treating the one or the other in isolation, while the reality is that both are involved and in need of treatment. At risk of appearing foolish, I believe that a lot of the problems we experience is because we grow lots of a specific type of plant in an artificial environment and then use artificial feeds and add to the problem by using pesticides, fungicides and other treatments and so create an environment that is very out of balance and easily capitalized as a niche environment by a pest or pathogen, much as hospitals are environments in which really nasty bugs can thrive.
First correct the imbalance (improve airflow, reintroduce effective microbes, watch and treat for insect infestations and drink more beer)